This application requests partial support for the 2014 Federation of American Societies of Experimental Biology (FASEB) Summer Conference on the Biology of the Immune System, which has been held every other summer for the past 26 years. The purpose of these meetings is to bring together basic immunologists from academia and the pharmaceutical industry at the professorial, post-doctoral and pre- doctoral levels to present and discuss cutting-edge research, emphasizing immunological mechanisms operating at the cellular and whole organism level. The meeting will focus on important new discoveries concerning the organs, cells, and molecules that play key roles in innate and adaptive immunity. The conference should also be attractive to savvy clinical researchers who know that the next generation of therapies will come from the kind of basic science discoveries presented at this conference. The time- tested format will consist of oral presentations by international leaders in the field, as well as invited short talks and poster presentations by other attendees. In addition, the 2014 meeting includes a newly instituted Meet the Experts mentoring session for trainees and young investigators. A major strength of the meeting is that the participants stay in a secluded resort and share meals for the length of the conference. This total immersion atmosphere is very conducive to in-depth discussions and collaboration building for attendees at all levels.